Combined Flu And COVID Vaccine Found More Effective In Late-Stage Trial, Says Moderna

Moderna says that a combination vaccine against both COVID and influenza generated a stronger immune response in adults aged 50 years and overs when compared to separate shots in a late-stage trial. Moderna President Stephen Hoge said the drugmaker hopes to launch the combination shot for the autumn respiratory disease season in 2025. Read on to know more.
Combined Flu And COVID Vaccine Found More Effective In Late-Stage Trial

Combined Flu And COVID Vaccine Found More Effective In Late-Stage Trial

The combination vaccine that provides protection against both COVID and influenza generated a stronger immune response in adults aged 50 years and overs when compared to separate shots in a late-stage trial, said Moderna. The phase-third trial shows that the vaccine helps the body with positive antibodies.
Speaking to BBC News, Chief executive Stephane Bancel said that he hoped the messenger ribonucleic acid (mRNA) vaccine could be made widely available in 2026 - or perhaps, 2025.
“We are very delighted about the results, because it’s the first time in the world that a company is able to show positive phase-three results combining in a single dose flu and Covid vaccine,” he said.
“You get one dose, one needle,” which meant “ease and peace of mind for the consumer”.
A report in Reuters says that in the study, the combination using messenger RNA technology generated greater antibodies than currently marketed traditional flu vaccines and Moderna’s Spikevax mRNA Covid shot, the company said.
The vaccine, called mRNA-1083, elicited a higher immune response against two A strains and one B strain of the flu in older adults when compared with widely used flu shots from GlaxoSmithKline and Sanofi, according to the company.
The Food and Drug Administration (FDA) in March recommended drugmakers target those three strains, called H1N1, H3N2, and B/Victoria, when developing their seasonal flu vaccines for 2024.
The latest data was collected from two arms of a larger study that involved around 8,000 people — one tested the combination against GSK’s Fluarix in adults aged 50 to 64 and another against Sanofi’s Fluzone HD in people 65 and older. Fluzone is a high-dose vaccine for older people.
Moderna President Stephen Hoge said the drugmaker hopes to launch the combination shot for the autumn respiratory disease season in 2025. “If not 2025, then 2026,” he said.
The company has been banking on new vaccines to make up for vastly lower demand and sales for its COVID shot. If approved, the combination vaccine would be Moderna’s third marketed product, having received FDA approval for its respiratory syncytial virus (RSV) vaccine last month.
Moderna also said the combination was found to be safe and tolerable in the latest study, and that rates of adverse side effects were similar to those of the other vaccines used in the trial. The most common side effects were injection site pain, fatigue, muscle aches and headache, Moderna said. The company said it expects to release the full results from the study at an upcoming medical conference.
(With inputs from agencies)
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